PXD011062-1

PXD011062 is an original dataset announced via ProteomeXchange.

Title	Protein kinase C-beta regulates environment mediated drug resistance in B cell malignancies
Description	Environment-mediated drug resistance (EMDR) limits the efficacy of cancer therapies by providing anti-apoptotic signals from a non-malignant microenvironment to tumour cells. We show that EMDR is regulated by protein kinase C in stromal cells is required for EMDR. We used plasma membrane profiling to demonstrate that PKC-beta regulates numerous plasma membrane proteins required for cell-cell communications and EMDR.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:36:34.530.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD011062
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	James Williamson
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex; Oxidation; Carbamidomethyl
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-11 07:55:24	ID requested
⏵ 1	2024-10-08 11:36:35	announced

10.6019/PXD011062;

10.1126/scitranslmed.aax9340;

Park E, Chen J, Moore A, Mangolini M, Santoro A, Boyd JR, Schjerven H, Ecker V, Buchner M, Williamson JC, Lehner PJ, Gasparoli L, Williams O, Bloehdorn J, Stilgenbauer S, Leitges M, Egle A, Schmidt-Supprian M, Frietze S, Ringshausen I, inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance. Sci Transl Med, 12(526):(2020) [pubmed]

submitter keyword: cancer,EMDR, stromal cells, plasma membrane

Ingo Ringshuasen
contact affiliation	Wellcome Trust/MRC Cambridge Stem Cell Institute & Department of Haematology, Univeristy of Cambridge, Cambridge, UK.
contact email	ir279@cam.ac.uk
lab head
James Williamson
contact affiliation	University of Cambridge
contact email	jcw76@cam.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD011062

PRIDE project URI

• PRIDE
  1. PXD011062
     1. Label: PRIDE project
     2. Name: Protein kinase C-beta regulates environment mediated drug resistance in B cell malignancies