⮝ Full datasets listing

PXD010838-2

PXD010838 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCharacterizing the molecular architecture of mitochondrial energy metabolism
DescriptionThe electron transfer chain is organized into inner mitochondrial membrane supercomplexes that promote substrate channeling and catalytic efficiency. This study shows that fatty acid oxidation enzymes physically interact with electron transfer chain supercomplexes at two points. The fatty acid oxidation trifunctional protein interacts with the NADH-binding domain of complex I of the electron transfer chain, while electron transfer flavoprotein dehydrogenase interacts with electron transfer chain complex III. These findings provide first view of an integrated molecular architecture for the major energy generating pathways in mitochondria.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:13:19.612.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJohan Palmfeldt
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-08-21 08:08:03ID requested
12019-07-31 01:50:39announced
22024-10-22 04:13:20announced2024-10-22: Updated project metadata.
Publication List
Wang Y, Palmfeldt J, Gregersen N, Makhov AM, Conway JF, Wang M, McCalley SP, Basu S, Alharbi H, St Croix C, Calderon MJ, Watkins S, Vockley J, Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex. J Biol Chem, 294(33):12380-12391(2019) [pubmed]
10.1074/jbc.ra119.008680;
Keyword List
ProteomeXchange project tag: Mitochondria (HPP)
curator keyword: Biological
submitter keyword: protein interactions, metabolism, mitochondria, supercomplexes
Contact List
Johan Palmfeldt
contact affiliationAarhus University, Denmark
contact emailjohan.palmfeldt@clin.au.dk
lab head
Johan Palmfeldt
contact affiliationAarhus University Hospital
contact emailjohan.palmfeldt@clin.au.dk
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD010838
PRIDE project URI
Repository Record List
[ + ]