⮝ Full datasets listing

PXD010723-1

PXD010723 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleData in support of Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients
DescriptionObjective. To analyse the pathogenesis of the diseases rheumatoid arthritis (RA) and spondyloarthritis (SpA) we investigated the protein composition in synovial fluid from the patients. Methods. Fifty-six synovial fluid (SF) were analysed with non-gel based proteomics from patients with RA (32) and SpA (24). Rheumatoid factor was measured in plasma, and cell-free DNA was measured in SF. Results. Two hundred proteins were quantified in the samples. The inflammatory proteins were more abundant in the RA group, specially proteins from neutrophil granulocytes. Cell-free DNA (cfDNA) in the SF was statistically associated with proteins that are known to form neutrophil extracellular traps (NETs). Plasma C-reactive protein (CRP), was correlated to other acute phase proteins in the SF. Minimal correlation was seen between acute phase proteins and proteins in NETs. Conclusions. The results show that in the synovial cavity in vivo neutrophils form NETs. This result sustains that neutrophils from RA patients are activated and are likely to undergo NETosis resulting in SF cfDNA specific of arthritis pathology with NETosis.
HostingRepositoryPRIDE
AnnounceDate2022-02-15
AnnouncementXMLSubmission_2022-02-15_06:53:46.039.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAllan Stensballe
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-08-08 05:39:19ID requested
12022-02-15 06:53:46announced
22024-10-22 05:31:18announced2024-10-22: Updated project metadata.
Publication List
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: Proteomics, Synovial Fluid, Rheumatoid Arthritis, Ankylosing Spondylitis
Contact List
Allan Stensballe
contact affiliationlaboratory for Medical Massspectrometry, Aalborg University, Denmark
contact emailas@hst.aau.dk
lab head
Allan Stensballe
contact affiliationAalborg University
contact emailas@hst.aau.dk
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD010723
PRIDE project URI
Repository Record List
[ + ]