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PXD010674-1

PXD010674 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAndrographis paniculata proteome
DescriptionAndrographis paniculata (AP) is a medicinal herb used to treat infectious diseases. The medicinal properties are due to presence of andrographolide and other secondary metabolites synthesized via mevalonic acid (MVA) and methyl erythritol phosphate (MEP) pathways. To increase the andrographolide content plants were treated with 50µM Jasmonic acid (JA) for one week. HPLC analysis revealed that one fold increase in the andrographolide content compared to control. To study the signal mechanism underlying in the stress response, samples were subjected to Q-TOF-LC-MS/MS analysis. JA influences the expression of MVA and MEP enzymes in treated (22 enzymes) than in untreated (3 enzymes). We found total 3308 proteins in control and 3994 in elicited sample in which 1393 were commonly found in both. The differential expression revealed 621 proteins were down-regulated and 201 proteins were up regulated. The functional annotation involved 40 metabolic processes where post translational modifications was highly up regulated in treated (5.7%). The total proteome of A.paniculata was reported for the first time. The comparison of elicited and non elicited (control) samples revealed that the elicitation is an integrated process which release variety of bioactive compounds to defend itself from variety of pathogens. The Knowledge obtained from this scrutiny, JA dependent stress adaptive response is likely to have industrial and agricultural impact. It creates a hope towards future for the development of eco-friendly ways of managing pests and tapping into a largely unexplored treasure of plant-derived bioactive metabolites for human use. Particularly in this plant, it is useful for the production of medicines to cure different kinds of diseases and disorders.
HostingRepositoryPRIDE
AnnounceDate2024-10-08
AnnouncementXMLSubmission_2024-10-08_11:40:24.740.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBindu Byreddi
SpeciesList scientific name: Andrographis paniculata; NCBI TaxID: 175694;
ModificationListiodoacetamide derivatized residue
InstrumentQ-Tof Ultima
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-08-03 02:53:30ID requested
12024-10-08 11:40:25announced
Publication List
10.1007/S11240-019-01741-0;
Keyword List
curator keyword: Biological
submitter keyword: Leaves Q-TOF-LC/MS
Contact List
Bindu Byreddi
contact affiliationCentre for plant Molecular Biology
contact emailbindu167@gmail.com
lab head
Bindu Byreddi
contact affiliationOsmania university
contact emailbindu167@gmail.com
dataset submitter
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Dataset FTP location
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