PXD010631 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Partial covariance two-dimensional mass spectrometry for bio-molecular primary structure |
Description | A new kind of two-dimensional mass spectrometry is described and applied to peptides, proteins and oligonucleotides. Partial covariance two-dimensional mass spectrometry (pC-2DMS) detects intrinsic statistical correlations between bio-molecular fragments originating from the same or consecutive decomposition events. This enables the identification of pairs of ions sharing a common origin across the entire fragment mass spectrum. The fragment-fragment correlations revealed by pC-2DMS are much more specific to the bio-molecular primary structure and its modifications than the individual fragment mass-to-charge ratios on which standard one-dimensional mass spectrometry (MS) is based. We illustrate the analytical power of pC-2DMS by demonstrating the identification of mixtures of combinatorial post-translational modification patterns inaccessible to standard MS. |
HostingRepository | PRIDE |
AnnounceDate | 2023-09-30 |
AnnouncementXML | Submission_2023-09-30_04:16:11.669.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | TaranDriver |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | 3'-nitro-L-tyrosine; acetylated residue; dimethylated residue |
Instrument | LTQ |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-07-31 06:19:56 | ID requested | |
⏵ 1 | 2023-09-30 04:16:12 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Technical |
submitter keyword: two-dimensional, combinatorial modifications |
Contact List
MarinaEdelson-Averbukh |
contact affiliation | Imperial College London, UK |
contact email | m.edelson-averbukh@imperial.ac.uk |
lab head | |
TaranDriver |
contact affiliation | Imperial College London |
contact email | t.driver14@imperial.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010631
- Label: PRIDE project
- Name: Partial covariance two-dimensional mass spectrometry for bio-molecular primary structure