PXD010527-1

PXD010527 is an original dataset announced via ProteomeXchange.

Title	SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.
Description	Mutations in SPOP, the gene most frequently point-mutated in primary prostate cancer, are associated with a high degree of genomic instability and deficiency in homologous recombination repair of DNA but the underlying mechanisms. SPOP knockdown leads to spontaneous replication stress and impaired recovery from replication fork stalling. An SPOP interactome analysis shows that wild type (WT) SPOP but not mutant SPOP associates with multiple proteins involved in transcription, mRNA splicing and export. Consistent with the association of SPOP with transcription, splicing and RNA export complexes, the decreased expression of several components of the DNA damage response pathway occurs at the level of transcription.
HostingRepository	PRIDE
AnnounceDate	2018-08-21
AnnouncementXML	Submission_2018-08-21_09:55:24.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Diego Iglesias-Gato
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-23 01:35:28	ID requested
⏵ 1	2018-08-21 09:55:25	announced
2	2024-10-22 04:46:53	announced	2024-10-22: Updated project metadata.

Hjorth-Jensen K, Maya-Mendoza A, Dalgaard N, Sigur, ð, sson JO, Bartek J, Iglesias-Gato D, Olsen JV, Flores-Morales A, SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability. Nucleic Acids Res, 46(18):9484-9495(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Prostate cancer

SPOP

LC-MS/MS

interactome

Diego Iglesias-Gato
contact affiliation	Faculty of health Science. University of Copenhagen
contact email	diego.iglesias@sund.ku.dk
lab head
Diego Iglesias-Gato
contact affiliation	University of Copenhagen
contact email	diego.iglesias@sund.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD010527

PRIDE project URI

• PRIDE
  1. PXD010527
     1. Label: PRIDE project
     2. Name: SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.