PXD010335-3

PXD010335 is an original dataset announced via ProteomeXchange.

Title	Biological Plasticity Rescues Target Activity in CRISPR Knock Outs
Description	Systematic investigation of residual protein expression in frameshift KO mutations derived from CRISPR-Cas9 in clonal cell lines
HostingRepository	PRIDE
AnnounceDate	2019-11-27
AnnouncementXML	Submission_2019-11-27_06:00:05.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maria Faelth Savitski
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; methionine oxidation with neutral loss of 64 Da; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2018-07-06 07:19:11	ID requested
1	2019-09-03 08:16:21	announced
2	2019-10-31 01:20:58	announced	2019-10-31: Updated publication reference for PubMed record(s): 31659326.
⏵ 3	2019-11-27 06:00:07	announced	2019-11-27: Updated project metadata.
4	2024-10-22 04:57:11	announced	2024-10-22: Updated project metadata.

Smits AH, Ziebell F, Joberty G, Zinn N, Mueller WF, Clauder-M, ü, nster S, Eberhard D, F, ä, lth Savitski M, Grandi P, Jakob P, Michon AM, Sun H, Tessmer K, B, ü, rckst, ü, mmer T, Bantscheff M, Steinmetz LM, Drewes G, Huber W, Biological plasticity rescues target activity in CRISPR knock outs. Nat Methods, 16(11):1087-1093(2019) [pubmed]

curator keyword: Biological

submitter keyword: HAP1, CRISPR-Cas9

Marcus Bantscheff
contact affiliation	Cellzome
contact email	marcus.x.bantscheff@gsk.com
lab head
Maria Faelth Savitski
contact affiliation	Cellzome
contact email	maria.x.faelth-savitski@gsk.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD010335

PRIDE project URI

• PRIDE
  1. PXD010335
     1. Label: PRIDE project
     2. Name: Biological Plasticity Rescues Target Activity in CRISPR Knock Outs