PXD010256 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Modulation of glioma cell proteome by Delta-24-RGD adenovirus (48hpi) |
Description | Glioblastoma multiforme (GBM) is the most common and aggressive type of malignant glioma. Oncolytic adenoviruses are being modified to exploit the aberrant expression of proteins in tumor cells to enhance tumor tropism and glioma-selective replication. E1A mutant adenovirus Delta-24-RGD has shown favorable toxicity profile and remarkable efficacy in a first-in-human phase I clinical trial. However, the comprehensive modulation of glioma metabolism in response to Delta-24-RGD infection is poorly understood. Integrating mass spectrometry based-quantitative proteomics, physical and functional interaction data, and biochemical approaches, we conducted a cell-wide study of intracellular and secreted glioma proteomes at late stage of Delta-24-RGD infection, when prominent autophagy has been described. |
HostingRepository | PRIDE |
AnnounceDate | 2018-12-11 |
AnnouncementXML | Submission_2019-02-12_08:24:15.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Enrique SantamarÃa |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-06-28 01:30:47 | ID requested | |
1 | 2018-12-11 06:42:45 | announced | |
⏵ 2 | 2019-02-12 08:24:17 | announced | Updated publication reference for PubMed record(s): 30503830. |
Publication List
Gonz, á, lez-Morales A, Zabaleta A, Garc, í, a-Moure M, Alonso MM, Fern, á, ndez-Irigoyen J, Santamar, í, a E, Oncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy. J Proteomics, 194():168-178(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Glioma, Adenovirus, Proteomics |
Contact List
Enrique Santamaria |
contact affiliation | Navarrabiomed-Clinical Neuroproteomics Laboratory, IdisNA, Proteored-ISCIII |
contact email | esantamma@navarra.es |
lab head | |
Enrique SantamarÃa |
contact affiliation | Proteomics unit |
contact email | esantamma@navarra.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010256
- Label: PRIDE project
- Name: Modulation of glioma cell proteome by Delta-24-RGD adenovirus (48hpi)