PXD010166-2

PXD010166 is an original dataset announced via ProteomeXchange.

Title	Septin-2 is overexpressed in epithelial ovarian cancer and mediates proliferation via regulation of cellular metabolism proteins
Description	Epithelial Ovarian Cancer (EOC) is associated with dismal survival rates due to the fact that patients are frequently diagnosed at an advanced stage and eventually become resistant to traditional chemotherapeutics. Hence, there is a crucial need for new and innovative therapies. Septin-2, a member of the septin family of GTP binding proteins, has been characterized in EOC for the first time and represents a potential future target. Septin-2 was found to be overexpressed in serous and clear cell human patient tissue compared to benign disease. Stable septin-2 knockout clones developed in an ovarian cancer cell line exhibited a significant decrease in proliferation rates. Comparative label-free proteomic analysis of septin-2 knockout cells revealed differential protein expression of pathways associated with the TCA cycle, acetyl CoA, proteasome and spliceosome,. Further validation of target proteins indicate that septin-2 plays a predominant role in post-transcriptional and translational modifications as well as cellular metabolism, and are the first to suggest the potential novel role of septin-2 in promoting EOC tumorigenesis through these mechanisms.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:46:05.409.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nagib Ahsan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-19 05:26:06	ID requested
1	2019-11-12 11:43:58	announced
⏵ 2	2024-10-22 04:46:13	announced	2024-10-22: Updated project metadata.

James NE, Cantillo E, Yano N, Chichester CO, DiSilvestro PA, Hovanesian V, Rao RSP, Kim KK, Moore RG, Ahsan N, Ribeiro JR, Septin-2 is overexpressed in epithelial ovarian cancer and mediates proliferation via regulation of cellular metabolic proteins. Oncotarget, 10(31):2959-2972(2019) [pubmed]

10.18632/oncotarget.26836;

curator keyword: Biological, Biomedical

submitter keyword: Septin2,Epithelial Ovarian Cancer, Proteomics

Nagib Ahsan
contact affiliation	Center FOr Cancer Research Development, Proteomics Core Facility, Rhode Island Hospital, Providence, RI, USA
contact email	nagib_ahsan@brown.edu
lab head
Nagib Ahsan
contact affiliation	Brown University
contact email	nagib_ahsan@brown.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD010166

PRIDE project URI

• PRIDE
  1. PXD010166
     1. Label: PRIDE project
     2. Name: Septin-2 is overexpressed in epithelial ovarian cancer and mediates proliferation via regulation of cellular metabolism proteins