PXD010138 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human brain Alzheimer's |
Description | Alzheimer’s disease (AD) is the most common neurodegenerative disorder being characterized by progressive impairment of memory and cognition, resulting in dementia. To investigate brain region vulnerability to AD and which pathways are altered in certain areas in AD, we performed proteomic profiling of human brain samples during AD progression in regions early (medial temporal lobe - MTL) and late affected (neocortex) by tau pathology. We employed a mass spectrometry-based approach to interrogate the human brain proteome during AD progression (B/B stages) in four distinct brain regions: entorhinal cortex (EC), parahippocampal cortex (PHC), temporal cortex (TC) and frontal cortex (FC). Importantly, we wanted to evaluate brain areas that are affected by tau pathology in different disease stages, in order to gain insights if there are common mechanisms or patterns shared between different brain regions during disease progression. A total of 103 samples were analyzed by nanoLC-MS/MS. |
HostingRepository | PRIDE |
AnnounceDate | 2019-07-01 |
AnnouncementXML | Submission_2019-07-01_08:04:02.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Melinda Rezeli |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-06-15 02:16:16 | ID requested | |
⏵ 1 | 2019-07-01 08:04:03 | announced | |
Publication List
Mendon, ç, a CF, Kuras M, Nogueira FCS, Pl, á I, Hortob, á, gyi T, Csiba L, Palkovits M, Renner É, D, ö, me P, Marko-Varga G, Domont GB, Rezeli M, Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease. Neurobiol Dis, 130():104509(2019) [pubmed] |
Keyword List
ProteomeXchange project tag: Human Brain Proteome Project (HUPO_HBPP) (B/D-HPP) |
submitter keyword: Alzheimer's disease, human brain, QE |
Contact List
Gyögy Marko-Varga |
contact affiliation | Lund University, Dept. Biomedical Engineering |
contact email | gyorgy.marko-varga@bme.lth.se |
lab head | |
Melinda Rezeli |
contact affiliation | Lund University |
contact email | melinda.rezeli@bme.lth.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD010138 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD010138
- Label: PRIDE project
- Name: Human brain Alzheimer's