PXD010118-1

PXD010118 is an original dataset announced via ProteomeXchange.

Title	Signaling Mechanisms in Initiation of Lithium-Induced Nephrogenic Diabetes Insipidus
Description	Lithium treatment is commonly used to treat bipolar disorder. However, this treatment disrupts kidney fuctionality. We used microdissected cortical collecting ducts to study proteomics and ultimately discover what changes occur in protein expression after 72-hr lithium treatment.
HostingRepository	PRIDE
AnnounceDate	2019-07-01
AnnouncementXML	Submission_2019-07-01_00:39:28.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gabirelle Gilmer
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-06-13 08:36:54	ID requested
⏵ 1	2019-07-01 00:39:29	announced
2	2024-10-22 04:45:56	announced	2024-10-22: Updated project metadata.

Sung CC, Chen L, Limbutara K, Jung HJ, Gilmer GG, Yang CR, Lin SH, Khositseth S, Chou CL, Knepper MA, RNA-Seq and protein mass spectrometry in microdissected kidney tubules reveal signaling processes initiating lithium-induced nephrogenic diabetes insipidus. Kidney Int, 96(2):363-377(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: kidney, cortical collecting duct, lithium, proteome

Mark Knepper
contact affiliation	Epithelial Systems Biology Laboratory, Systems Biology Center NHLBI, NIH, DHHS, USA
contact email	knepperm@nhlbi.nih.gov
lab head
Gabirelle Gilmer
contact affiliation	National Heart, Lung, and Blood Institute
contact email	gabrielle.gilmer@nih.gov
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD010118

PRIDE project URI

• PRIDE
  1. PXD010118
     1. Label: PRIDE project
     2. Name: Signaling Mechanisms in Initiation of Lithium-Induced Nephrogenic Diabetes Insipidus