PXD009872-1
PXD009872 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | SET1A-mediated mono-methylation at K342 regulates YAP activation by blocking its nuclear export and promotes tumorigenesis |
| Description | YAP, a key effector of Hippo pathway, is activated by its translocation from cytoplasm to nucleus to regulate gene expression and promote tumorigenesis. Although the mechanism by which YAP is suppressed in cytoplasm has been well-studied, how the activated YAP is sequestered in the nucleus remains unknown. Here, we demonstrate that YAP is a nucleocytoplasmic shuttling protein and its nuclear export is controlled by SET1A-mediated mono-methylation of YAP at K342, which disrupts the binding of YAP to CRM1. YAP mimetic methylation knockin mice are more susceptible to colorectal tumorigenesis. Clinically, YAP K342 methylation is reversely correlated with cancer survival. Collectively, our study identifies SET1A mediated-mono-methylation at K342 as an essential regulatory mechanism for regulating YAP activity and tumorigenesis. |
| HostingRepository | MassIVE |
| AnnounceDate | 2018-05-23 |
| AnnouncementXML | Submission_2018-05-23_21:46:06.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | wanda |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Methyl |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2018-05-23 21:43:10 | ID requested | |
| ⏵ 1 | 2018-05-23 21:46:07 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: YAP methylation, SET1A, nuclear export, tumorigenesis |
Contact List
| Ping Wang | |
|---|---|
| contact affiliation | 1Shanghai Tenth People Hospital of Tongji University, School of Medicine and School of Life Science and Technology, Tongji University |
| contact email | wangp@tongji.edu.cn |
| lab head | |
| wanda | |
| contact affiliation | ECNU |
| contact email | 782899013@qq.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000082393 |
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