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PXD009857 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRPK1 phosphorylation and cell death
DescriptionThe molecular mechanisms regulating the switch between RIPK1 pro-survival and pro-death functions remain poorly understood. We identified Ikkα/β-mediated phosphorylation of RIPK1 as a key mechanism inhibiting RIPK1 kinase activity and preventing TNF-mediated RIPK1 kinase-dependent cell death.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPiero Giansanti
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-05-22 04:29:47ID requested
12019-04-02 08:42:06announced
22019-04-23 02:43:17announcedUpdated publication reference for PubMed record(s): 30988283.
Publication List
Dondelinger Y, Delanghe T, Priem D, Wynosky-Dolfi MA, Sorobetea D, Rojas-Rivera D, Giansanti P, Roelandt R, Gropengiesser J, Ruckdeschel K, Savvides SN, Heck AJR, Vandenabeele P, Brodsky IE, Bertrand MJM, Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation. Nat Commun, 10(1):1729(2019) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Mouse, LC-MSMS, RPK1, cell deth
Contact List
Albert J.R. Heck
contact affiliationBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands Netherlands Proteomics Centre, Padualaan 8, 3584 CH Utrecht, The Netherlands
contact emailA.J.R.Heck@uu.nl
lab head
Piero Giansanti
contact affiliationTechnical University of Munich
contact emailpiero.giansanti@tum.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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