PXD009857 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | RPK1 phosphorylation and cell death |
Description | The molecular mechanisms regulating the switch between RIPK1 pro-survival and pro-death functions remain poorly understood. We identified Ikkα/β-mediated phosphorylation of RIPK1 as a key mechanism inhibiting RIPK1 kinase activity and preventing TNF-mediated RIPK1 kinase-dependent cell death. |
HostingRepository | PRIDE |
AnnounceDate | 2019-04-02 |
AnnouncementXML | Submission_2019-04-23_02:43:15.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Piero Giansanti |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-05-22 04:29:47 | ID requested | |
1 | 2019-04-02 08:42:06 | announced | |
⏵ 2 | 2019-04-23 02:43:17 | announced | Updated publication reference for PubMed record(s): 30988283. |
3 | 2024-10-22 04:13:20 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dondelinger Y, Delanghe T, Priem D, Wynosky-Dolfi MA, Sorobetea D, Rojas-Rivera D, Giansanti P, Roelandt R, Gropengiesser J, Ruckdeschel K, Savvides SN, Heck AJR, Vandenabeele P, Brodsky IE, Bertrand MJM, Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation. Nat Commun, 10(1):1729(2019) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Mouse, LC-MSMS, RPK1, cell deth |
Contact List
Albert J.R. Heck |
contact affiliation | Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands Netherlands Proteomics Centre, Padualaan 8, 3584 CH Utrecht, The Netherlands |
contact email | A.J.R.Heck@uu.nl |
lab head | |
Piero Giansanti |
contact affiliation | Technical University of Munich |
contact email | piero.giansanti@tum.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/04/PXD009857 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009857
- Label: PRIDE project
- Name: RPK1 phosphorylation and cell death