PXD009784 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies |
Description | Nephronophthisis is one of the leading genetic causes of end-stage renal disease in childhood. Early diagnostics and prognostics for nephronophthisis are currently limited. We aimed to identify non-invasive protein biomarkers for nephronophthisis in urinary extracellular vesicles. Extracellular vesicles were isolated from urine of 12 patients with a nephronophthisis-related ciliopathy and 12 age- and gender-matched controls, followed by in-depth label-free LC-MS/MS proteomics analysis of gel fractionated extracellular vesicles proteins. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:45:18.916.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sander Piersma |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-05-15 03:42:49 | ID requested | |
1 | 2018-08-06 06:49:13 | announced | |
⏵ 2 | 2024-10-22 04:45:23 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1016/j.jprot.2018.07.008; |
Stokman MF, Bijnsdorp IV, Schelfhorst T, Pham TV, Piersma SR, Knol JC, Giles RH, Bongers EMHF, Knoers NVAM, Lilien MR, Jim, é, nez CR, Renkema KY, Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies. J Proteomics, 192():27-36(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Human, extracellular vesicle, label-free proteomics, nephronophthisis, kidney, ciliopathies |
Contact List
Connie Ramona Jimenez |
contact affiliation | OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands |
contact email | c.jimenez@vumc.nl |
lab head | |
Sander Piersma |
contact affiliation | OncoProteomics Laboratory, dept of Medical Oncology, VUmc Medical Center, Amsterdam, The Netherlands |
contact email | s.piersma@vumc.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009784
- Label: PRIDE project
- Name: Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies