PXD009704 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | IIS-mediated modulation of DIGs proteome in C. elegans. |
Description | Reducing insulin/IGF-1 signaling (IIS) extends lifespan, promotes protein homeostasis (proteostasis) and elevates stress resistance of worms, flies and mammals. How these functions are orchestrated across the organism is only partially understood. One prominent group of IIS-regulated encode for lipid metabolizing enzymes. Thus, we asked whether IIS reduction modulates the protein content and functionality of membranal lipid assemblies. We discovered that in the nematode Caenorhabditis elegans, the IIS positively regulates the expression of caveolin-1 (cav-1), a gene which is primarily expressed in neurons of the adult worm and underlies the formation of caveolae, a subtype of lipid microdomains that serve as platforms for signaling complexes. Accordingly, IIS reduction lowers cav-1 expression and lessens the quantity of neuronal caveolae. Reduced cav-1 expression extends lifespan and mitigates toxic protein aggregation by modulating the expression of aging-regulating and signaling-promoting genes. Our findings define caveolae as aging-governing signaling centers and underscore the potential for cav-1 as a novel therapeutic target for the promotion of healthy aging. |
HostingRepository | PRIDE |
AnnounceDate | 2018-05-09 |
AnnouncementXML | Submission_2018-08-27_07:38:21.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ehud Cohen |
SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap XL |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-05-07 06:37:15 | ID requested | |
1 | 2018-05-09 00:14:02 | announced | |
⏵ 2 | 2018-08-27 07:38:22 | announced | Updated publication reference for PubMed record(s): 29945933. |
Publication List
Keyword List
curator keyword: Biological |
submitter keyword: Aging, Insulin/IGF signaling, C. elegans, Detergent Resistant Granules. |
Contact List
Ehud Cohen |
contact affiliation | Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada (IMRIC). School of Medicine. The Hebrew University of Jerusalem, Israel. |
contact email | ehudc@ekmd.huji.ac.il |
lab head | |
Ehud Cohen |
contact affiliation | The Hebrew University of Jerusalem. The Institute for Medical Research Israel-Canada (IMRIC), School of Medicine. |
contact email | robertr@ekmd.huji.ac.il |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009704
- Label: PRIDE project
- Name: IIS-mediated modulation of DIGs proteome in C. elegans.