PXD009703-1

PXD009703 is an original dataset announced via ProteomeXchange.

Title	Comparative proteomic analysis revealed complex responses to classical/novel duck reovirus infections in the spleen cells of Cairna moschata
Description	Duck reovirus (DRV), a member of the genus Orthoreovirus in the family Reoviridae, was first isolated from Muscovy ducks. The disease associated with DRV causes great economic losses to the duck industry. However, the responses of duck (Cairna moschata) to the classical/novel DRV (C/NDRV) infections are largely unknown. To reveal the relationship of pathogenesis and immune response, the proteomes of duck spleen cells under the control and C/NDRV infections were compared. In total, 5986 proteins were identified, of which 5389 proteins were quantified. The different expressed proteins (DEPs) under the C/NDRV infections showed displayed various biological functions and diverse subcellular localizations. The proteins related to the serine protease system were siginificantly changed, suggesting that the activated serine protease system may play an important role under the C/NDRV infections. Furthermore, the differences in the responses to the C/NRDV infections between the duck liver and spleen cells were compared. Only a small number of common DEPs were identified in both liver and spleen cells, suggesting diversified pattern involved in the responses to the C/NRDV infections. However, the changes in the proteins involved in the serine protease systems were similar in both liver and spleen cells. Our data may give a comprehensive resource for investigating the responses to C/NDRV infections in ducks.
HostingRepository	PRIDE
AnnounceDate	2020-08-24
AnnouncementXML	Submission_2020-08-23_23:02:15.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chenyu Lu
SpeciesList	scientific name: Cairina moschata; NCBI TaxID: 8855;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-05-07 06:33:13	ID requested
⏵ 1	2020-08-23 23:02:16	announced

Xiao C, Huang Y, Wei Q, Liu Y, Ji Q, Li K, Bao G, Comparative Proteomic Analysis Reveals Complex Responses to Bordetella bronchiseptica Infections in the Spleen of Rabbits. Proteomics, 20(24):e2000117(2020) [pubmed]

curator keyword: Biological

submitter keyword: Cairna moschata

differential expressed protein

duck reovirus

proteome

serine protease

spleen

Tao Yun
contact affiliation	Zhejiang Academy of Agricultural Sciences
contact email	yt-t@163.com
lab head
Chenyu Lu
contact affiliation	Zhejiang University
contact email	lcyyz@hotmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD009703
     1. Label: PRIDE project
     2. Name: Comparative proteomic analysis revealed complex responses to classical/novel duck reovirus infections in the spleen cells of Cairna moschata