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PXD009654-1

PXD009654 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman serum glycosylation
DescriptionIn this work, we presented an integrated workflow for simultaneous analysis of sialylated glycosites and site-specific glycoforms by taking advantages of SGP enrichment approach with high specificity and paired spectra intact glycopeptide identification strategy with high efficiency. By using this strategy, comprehensive analysis of sialylation of glycoproteins was achieved, which could reveal the high heterogeneity of sialylated glycosylation. Additionally, significant changes were obtained on the levels of sialylated glycosites, as well as site-specific glycoforms between pooled hepatocellular carcinoma (HCC) and normal human serum samples. Taken together, our method could be a powerful tool for comprehensive analysis of sialylation glycosylation in human serum and other biological samples.
HostingRepositoryiProX
AnnounceDate2018-05-03
AnnouncementXMLSubmission_2018-05-02_23:23:13.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHongqiang Qin
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListdeaminated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-05-02 23:22:54ID requested
12018-05-02 23:23:13announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human serum, site-specific glycosylation, sialylation
Contact List
Mingliang Ye
contact affiliationDalian Institute of Chemical Physics, CAS
contact emailmingliang@dicp.ac.cn
lab head
Hongqiang Qin
contact affiliationDalian Institute of Chemical Physics, CAS
contact emailqinhongqiang2004@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI