PXD009493-2

PXD009493 is an original dataset announced via ProteomeXchange.

Title	D2Ome - rate constant estimation from heavy water metabolic labeling and LC-MS
Description	We developed a software for extraction of protein decay rate constants from heavy water labeling followed by LC-MS experiments. We illustrate the program on application to normal diet and western diet fed LDLR-/- mice. We demonstrate that proteins subunits of 40S ribosomal complex have reduced stability in western diet fet mice.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:44:32.765.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD009493
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Ahmad Borzoo
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	GG; Deamidated; Oxidation; Acetyl; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-13 02:07:48	ID requested
1	2019-04-10 05:41:09	announced
⏵ 2	2024-10-22 04:44:34	announced	2024-10-22: Updated project metadata.

10.6019/PXD009493;

10.1021/acs.jproteome.0c00873;

Sadygov RG, Using Heavy Mass Isotopomers for Protein Turnover in Heavy Water Metabolic Labeling. J Proteome Res, 20(4):2035-2041(2021) [pubmed]

curator keyword: Technical

submitter keyword: Heavy water labeling, Protein turnover, Software

Rovshan G. Sadygov
contact affiliation	UTMB
contact email	rovshan.sadygov@utmb.edu
lab head
Ahmad Borzoo
contact affiliation	UTMB
contact email	ahborzou@utmb.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/04/PXD009493

PRIDE project URI

• PRIDE
  1. PXD009493
     1. Label: PRIDE project
     2. Name: D2Ome - rate constant estimation from heavy water metabolic labeling and LC-MS