PXD009411-2

PXD009411 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of brain microvessels from htra1 KO mice
Description	CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathyis) a small-vessel disease caused by loss of function mutaions of htrA1, which cleaves several extracellular matrix proteins. Here, we isolated microvessels from htra1 KO and wild type control mice to study the effect of htra1 loss of function on microvessels.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:44:30.243.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stephan Mueller
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-05 01:27:23	ID requested
1	2018-08-03 08:06:03	announced
⏵ 2	2024-10-22 04:44:32	announced	2024-10-22: Updated project metadata.

10.1007/s00401-018-1853-8;

Zellner A, Scharrer E, Arzberger T, Oka C, Domenga-Denier V, Joutel A, Lichtenthaler SF, M, ü, ller SA, Dichgans M, Haffner C, CADASIL brain vessels show a HTRA1 loss-of-function profile. Acta Neuropathol, 136(1):111-125(2018) [pubmed]

curator keyword: Biological

submitter keyword: small vessel disease,microvessel, CARASIL

Christof Haffner
contact affiliation	Institute for Stroke and Dementia Research (ISD) Klinikum der Universität München Feodor-Lynen-Str. 17 81377 Munich Germany
contact email	christof.haffner@med.uni-muenchen.de
lab head
Stephan Mueller
contact affiliation	DZNE Munich Neuroproteomics
contact email	stephan.mueller@dzne.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD009411

PRIDE project URI

• PRIDE
  1. PXD009411
     1. Label: PRIDE project
     2. Name: Proteome analysis of brain microvessels from htra1 KO mice