PXD009386-1

PXD009386 is an original dataset announced via ProteomeXchange.

Title	Quantitative S-nitrosylation proteome reveals the susceptibility of translational machinery to oxidized low-density lipoprotein in vascular endothelial cells
Description	Oxidized low-density lipoprotein (ox-LDL) can impair endothelial function and lead to the development of atherosclerosis. Protein S-nitrosylation is sensitive to the cellular redox state and acts as a crucial regulator and executor of NO signaling pathways. Aberrant S-nitrosylation contributes to the pathogenesis of cardiovascular and cerebrovascular diseases. However, the effect of ox-LDL on S-nitrosylation and its significance for endothelial dysfunction have not been studied at the S-nitrosylation proteome level. In our study, many key proteins belonged to ribosomal structure and translational regulatory proteins, covering the entire translation process. These results indicated that S-nitrosylation of the translational machinery in vascular endothelial cells was susceptible to ox-LDL.
HostingRepository	iProX
AnnounceDate	2018-04-04
AnnouncementXML	Submission_2018-04-03_23:45:48.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	xiaohuixu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	S-nitrosyl-L-cysteine
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2018-04-03 23:45:37	ID requested
⏵ 1	2018-04-03 23:45:48	announced

Dataset with its publication pending

submitter keyword: Endothelial cell, LC-MS/MS, Ox-LDL, S-nitrosylation, Translational machinery

Lianli Chi
contact affiliation	National Glycoengineering Research Center, Shandong University
contact email	lianlichi@sdu.edu.cn
lab head
xiaohuixu
contact affiliation	Shandong University
contact email	xiaohuixu@163.com
dataset submitter

iProX dataset URI