PXD009333 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Fam20C-LCMSMS - Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α |
Description | Family with sequence similarity 20C (Fam20C), the physiological Golgi casein kinase, phosphorylates numerous secreted proteins that are involved in a wide variety of biological processes. However, the role of Fam20C in regulating proteins in the endoplasmic reticulum (ER) lumen is largely unknown. Here we report that Fam20C interacts with various luminal proteins and that its depletion results in a more reduced ER lumen. We further show that ER oxidoreductin 1α (Ero1α), the pivotal sulfhydryl oxidase that catalyzes disulfide formation in the ER, is phosphorylated at Ser145 under reductive stress and under secretion-demanding conditions, such as mammalian lactation. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:43:52.596.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jianchao Zhang |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-03-26 07:33:10 | ID requested | |
1 | 2018-05-30 09:16:59 | announced | |
2 | 2018-06-05 08:24:56 | announced | Updated publication reference for PubMed record(s): 29858230. |
⏵ 3 | 2024-10-22 04:44:00 | announced | 2024-10-22: Updated project metadata. |
Publication List
Zhang J, Zhu Q, Wang X, Yu J, Chen X, Wang J, Wang X, Xiao J, Wang CC, Wang L, . EMBO J, 37(14):(2018) [pubmed] |
10.15252/embj.201798699; |
Keyword List
curator keyword: Biological |
submitter keyword: Fam20C Ero1 LCMSMS |
Contact List
Lei Wang |
contact affiliation | National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China |
contact email | wanglei@moon.ibp.ac.cn |
lab head | |
Jianchao Zhang |
contact affiliation | Institue of Biophysics, Chinese Academy of Sciences |
contact email | zhangjianchao@moon.ibp.ac.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009333
- Label: PRIDE project
- Name: Fam20C-LCMSMS - Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α