PXD009026 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | DNA mismatch repair activity of MutLalpha is regulated by CK2-dependent phosphorylation of MLH1 |
Description | Mass spectrometry based PTM phosphorylation analysis to study regulation mechanism of MUTL alpha, a heterodimer consisting of MLH1 and PMS2 and a key player in DNA mismatch repair (MMR). It could be demonstrated that phosphorylation of MLH1 by Casein Kinase II (CK2) at amino acid position 477 can switch off MMR activity in vitro. |
HostingRepository | PRIDE |
AnnounceDate | 2018-08-29 |
AnnouncementXML | Submission_2018-08-28_23:32:11.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sebastian Funke |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-02-23 05:48:57 | ID requested | |
⏵ 1 | 2018-08-28 23:32:13 | announced | |
Publication List
We, ß, becher IM, Hinrichsen I, Funke S, Oellerich T, Plotz G, Zeuzem S, Grus FH, Biondi RM, Brieger A, is regulated by CK2-dependent phosphorylation of MLH1 (S477). Mol Carcinog, 57(12):1723-1734(2018) [pubmed] |
Keyword List
ProteomeXchange project tag: Human Proteome Project |
curator keyword: Biological |
submitter keyword: MUTL alpha, HEK293T cells, immunoprecipitation, phosphorylation, LC-MS/MS |
Contact List
Franz H. Grus |
contact affiliation | Experimental Ophthalmology Ophthalmology University Medical Center Mainz Germany |
contact email | grus@eye-research.org |
lab head | |
Sebastian Funke |
contact affiliation | Experimental Ophthalmology, Ophthalmology, University Medical Center Mainz |
contact email | sfunke@eye-research.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD009026 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD009026
- Label: PRIDE project
- Name: DNA mismatch repair activity of MutLalpha is regulated by CK2-dependent phosphorylation of MLH1