PXD008989-1

PXD008989 is an original dataset announced via ProteomeXchange.

Title	PROTEOMIC ANALYSIS OF EARLY DIABETIC RETINOPATHY REVEALS MEDIATORS OF NEURODEGENERATIVE BRAIN DISEASES
Description	The aim of the present study was to identify early changes in diabetic retinas using an unbiased proteomics approach. Proteomic profiles of control retinas were compared to diabetic retinas obtained from patients known to have no classic vascular lesions that clinically define diabetic retinas. The diabetic retinas were further split into two groups according to the presence or absence of glial activation as marker of progressive changes that may be associated with the early neurodegenerative process. By examining differentially expressed proteins at this preclinical stage, our aim was to acquire a clearer understanding of the complex cellular processes that initiate diabetic retinas.
HostingRepository	PRIDE
AnnounceDate	2022-03-02
AnnouncementXML	Submission_2022-03-02_02:27:47.069.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD008989
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Tatiana Laremore
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2018-02-20 01:31:18	ID requested
⏵ 1	2022-03-02 02:27:47	announced
2	2023-11-14 08:49:21	announced	2023-11-14: Updated project metadata.

Weber SR, Zhao Y, Ma J, Gates C, da Veiga Leprevost F, Basrur V, Nesvizhskii AI, Gardner TW, Sundstrom JM, A validated analysis pipeline for mass spectrometry-based vitreous proteomics: new insights into proliferative diabetic retinopathy. Clin Proteomics, 18(1):28(2021) [pubmed]

curator keyword: Biomedical

submitter keyword: human retina, diabetes

Jeffrey M. Sundstrom
contact affiliation	Penn State Eye Center, Penn State College of Medicine, Hershey Pennsylvania, USA
contact email	jsundstrom@pennstatehealth.psu.edu
lab head
Tatiana Laremore
contact affiliation	Penn State
contact email	tnl1@psu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD008989

PRIDE project URI

• PRIDE
  1. PXD008989
     1. Label: PRIDE project
     2. Name: PROTEOMIC ANALYSIS OF EARLY DIABETIC RETINOPATHY REVEALS MEDIATORS OF NEURODEGENERATIVE BRAIN DISEASES