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PXD008835-2

PXD008835 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleData in support of Identification of brain antigens recognized by autoantibodies in experimental autoimmune encephalomyelitis-induced animals treated with Etomoxir or Interferon-beta
DescriptionMultiple Sclerosis is a neurogenerative disease, where inflammation plays an essential role and the loss of tolerance for self produces proteins is a key feature. To investigate the autoimmune response, we use serum from experimental autoimmune encephalomyelitis (EAE) induced rats and investigate autoantibody chance in connection with induced disease and treatment with Etomoxir or Interferon-beta. Several significant differences in suggested antigens were identified comparing healthy, diseased and treated groups, suggesting a role of these antigens in the progression of Multiple Sclerosis.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_03:59:18.787.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAllan Stensballe
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListiodoacetamide derivatized residue; deamidated residue; L-citrulline
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02018-02-01 09:42:40ID requested
12018-05-14 02:32:00announced
22024-10-22 03:59:26announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41598-018-25391-y;
M, ΓΈ, rkholt AS, Kastaniegaard K, Trabjerg MS, Gopalasingam G, Niganze W, Larsen A, Stensballe A, Nielsen S, Nieland JD, . Sci Rep, 8(1):7092(2018) [pubmed]
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: Multiple Sclerosis, Autoantibodies, Experimental autoimmune encephalomyelitis, rat model, Inflammation, Autoantigens, Etomoxir
Contact List
Allan Stensballe
contact affiliationLaboratory for Medical Mass Spectrometry Department of Health Science and Technology Aalborg University | Denmark
contact emailas@hst.aau.dk
lab head
Allan Stensballe
contact affiliationAalborg University
contact emailas@hst.aau.dk
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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