PXD008796 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | TRANSCRIPTIONAL ACTIVATION BY E2F4 INDEPENDENT OF THE RB FAMILY |
Description | E2F transcription factors are central regulators of cell cycle progression and cell fate decisions in mammalian cells. E2F4 is a transcriptional repressor implicated in cell cycle arrest and whose repressive activity depends on its interaction with members of the RB family. E2F4 often represents the predominant E2F activity in cells. Here we show that E2F4 is important for the proliferation and the survival of mouse embryonic stem cells. In these cells, E2F4 acts in part as a transcriptional activator that promotes the expression of cell cycle genes. Importantly, this role for E2F4 is completely independent of the RB family. Accordingly, an unbiased analysis of the E2F4 interactome shows that E2F4 functionally interacts with chromatin regulators associated with gene activation in RB family-mutant cells. Taken together, our findings uncover a non-canonical role for E2F4 that reveal novel insights into the biology of rapidly dividing cell types. |
HostingRepository | PRIDE |
AnnounceDate | 2019-04-26 |
AnnouncementXML | Submission_2019-07-08_00:20:41.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD008796 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Janos Demeter |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | Phospho; Propionamide; Glu->pyro-Glu; Deamidated; Methyl; Biotin; Oxidation; Acetyl; GlyGly; Gln->pyro-Glu |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-01-30 05:54:00 | ID requested | |
1 | 2019-04-26 01:34:32 | announced | |
⏵ 2 | 2019-07-08 00:20:42 | announced | Updated publication reference for PubMed record(s): 31270324. |
Publication List
Hsu J, Arand J, Chaikovsky A, Mooney NA, Demeter J, Brison CM, Oliverio R, Vogel H, Rubin SM, Jackson PK, Sage J, E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family. Nat Commun, 10(1):2939(2019) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: E2F4, RB, cell cycle, embryonic stem cells, p107, p130, pluripotency |
Contact List
Julien Sage |
contact affiliation | Department of Pediatrics and Genetics, Stanford University, Stanford, CA 94305, USA |
contact email | julsage@stanford.edu |
lab head | |
Janos Demeter |
contact affiliation | Stanford University |
contact email | jdemeter@stanford.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008796
- Label: PRIDE project
- Name: TRANSCRIPTIONAL ACTIVATION BY E2F4 INDEPENDENT OF THE RB FAMILY