PXD008642 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human breast cancer cell line and tissue, ISE-affinity proteogenomics |
Description | Introducing a clinical-practical, alternative splicing activity-based proteogenomic method that identifies, in their oncogenically active states, biomarker genes bearing patient-specific GE or copy-number alterations of prognostic significance. This integrated multi-omics method uses intronic splicing enhancers (ISEs) probes to sort in situ ISE-interacting trans-acting protein factors (trans-interactome) directly from a heterogeneous tumor for subsequent mass spectrometry (MS) characterization. |
HostingRepository | PRIDE |
AnnounceDate | 2018-03-20 |
AnnouncementXML | Submission_2018-03-20_01:14:18.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Li Wang |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | 6x(13)C labeled L-lysine; 6x(13)C: 4x(15)N labeled L-arginine; 6x(13)C: 2x(15)N labeled L-lysine; monohydroxylated residue; iodoacetamide derivatized residue; 6x(13)C labeled L-arginine |
Instrument | LTQ Orbitrap Velos; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-01-10 01:21:43 | ID requested | |
⏵ 1 | 2018-03-20 01:14:19 | announced | |
Publication List
Wang L, Wrobel JA, Xie L, Li D, Zurlo G, Shen H, Yang P, Wang Z, Peng Y, Gunawardena HP, Zhang Q, Chen X, Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer. Cell Chem Biol, 25(5):619-633.e5(2018) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: ISE-Affinity proteomics, precision marker, ISE trans-interactomes |
Contact List
Xian Chen |
contact affiliation | Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill,NC 27599,USA |
contact email | liwang@email.unc.edu |
lab head | |
Li Wang |
contact affiliation | Postdoctoral Research Associate |
contact email | liwang@email.unc.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/03/PXD008642 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008642
- Label: PRIDE project
- Name: Human breast cancer cell line and tissue, ISE-affinity proteogenomics