PXD008613 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Malaria Hepatocyte HC-04.J7 Project |
Description | Characterization of three hepatocyte cell lines (2 parental and 1 clone), under two different media conditions. Parental cell lines HepG2 and HC-04, single cell cloned from HC-04 defined as HC-04.J7. The goal of the project initially was to investigate the invasion of hepatocytes by Plasmodium falciparum sporozoites, and once found that the HC-04 cell had a higher invasion than HepG2, single cell isolates were generated from HC-04 before being expanded. The resulting HC-04.J7 isolate further improved the invasion rate. Transcriptomic and proteomic data sets were generated from all cell lines in both media, than analyzed for potential receptors or biochemical pathways that play a role in the increased invasion of HC-04 and specifically, HC-04.J7. |
HostingRepository | PRIDE |
AnnounceDate | 2019-11-12 |
AnnouncementXML | Submission_2019-11-12_10:33:04.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD008613 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Timothy Hamerly |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | Ammonia-loss; Dehydrated; Oxidation; Acetyl; Carbamidomethyl |
Instrument | 6220 Time-of-Flight LC/MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-01-08 07:33:26 | ID requested | |
⏵ 1 | 2019-11-12 10:33:06 | announced | |
Publication List
Tweedell RE, Tao D, Hamerly T, Robinson TM, Larsen S, Gr, ΓΈ, nning AGB, Norris AM, King JG, Law HCH, Baumbach J, Bergmann-Leitner ES, Dinglasan RR, Sporozoite Invasion That Is Associated With Expression of Glypican-3. Front Microbiol, 10():127(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Malaria, Plasmodium falciparum, Human Liver, Hepatocyte, LC-MS/MS |
Contact List
Rhoel David Ramos Dinglasan |
contact affiliation | Department of Infectious Diseases and Immunology, Emerging Pathogens Institute, University of Florida, United States of America |
contact email | rdinglasan@epi.ufl.edu |
lab head | |
Timothy Hamerly |
contact affiliation | Rhoel Dinglasan Lab, University of Florida |
contact email | timothy.hamerly@ufl.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008613
- Label: PRIDE project
- Name: Malaria Hepatocyte HC-04.J7 Project