PXD008583-1

PXD008583 is an original dataset announced via ProteomeXchange.

Title	Several proteins are altered in serum of patients having colorectal cancer with variable levels of C-Reactive protein and different survival times
Description	Colorectal cancer (CRC) is the third most common cancer worldwide. Increased levels of C-reactive protein (CRP), which occur during local and systemic inflammation, have been linked to poor prognosis in CRC patients. on the other hand there are no biomarkers associated with 5 year survival of CRC patients. We divided the serum samples into either high (>30 mg/L) or low CRP (<30 mg/L) or long and short 5-year survival. In this study, we have quantified 256 proteins with two or more unique peptides. Data were further analyzed by ANOVA, principal component analysis (PCA), Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA)-modeling and OPLS-DA-associated S-plot. Pathway analysis was performed using Integrated Molecular Pathway Level Analysis (IMPaLa) and Ingenuity Pathway Analysis (IPA). We propose several proteins associated with prognosis and survival in patients with CRC.
HostingRepository	PRIDE
AnnounceDate	2018-03-26
AnnouncementXML	Submission_2018-03-26_05:34:53.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sakari Joenväärä
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2018-01-03 01:23:52	ID requested
⏵ 1	2018-03-26 05:34:54	announced
2	2024-10-22 04:13:10	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Colerectal Cancer

serum proteomics

multivariate data analysis

OPLS-DA

Insulin growth factor binding protein-2

Risto Renkonen
contact affiliation	Transplantation laboratory, Haartmaninkatu 3, PO Box 21, FI-00014 University of Helsinki, Finland
contact email	risto.renkonen@helsinki.fi
lab head
Sakari Joenväärä
contact affiliation	Helsinki University
contact email	sakari.joenvaara@helsinki.fi
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD008583
     1. Label: PRIDE project
     2. Name: Several proteins are altered in serum of patients having colorectal cancer with variable levels of C-Reactive protein and different survival times