PXD008568 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human plasma LC-MSMS |
Description | Patent ductus arteriosus (PDA) is the third most common congenital heart disease and resulted from the persistence of ductal patency after birth. Ductus arteriosus closure involves functional and structural remodeling, controlled by many factors. The closure-related human plasma proteins are unknown. Here we for the first time demonstrate six key differential plasma proteins in the human PDA patients using proteomic technology and present a model to illustrate the constriction and closure of ductus arteriosus. We found that permanent closure might be regulated by the proteins related to platelet activation and coagulation cascades, complement mannan-binding-lectin, and other systemic signaling pathways. Our findings indicate that the differential proteins involved in these pathways may play key roles in the non-closure of the ductus arteriosus and may be developed as biomarkers for diagnosis. All those findings may be served as the basis of understanding the etiology and pathogenesis of PDA. |
HostingRepository | PRIDE |
AnnounceDate | 2018-11-30 |
AnnouncementXML | Submission_2018-11-30_05:10:30.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hai-Tao Hou |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iTRAQ8plex-116 reporter+balance reagent acylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2018-01-02 02:28:03 | ID requested | |
⏵ 1 | 2018-11-30 05:10:31 | announced | |
2 | 2018-12-04 08:14:12 | announced | Updated publication reference for PubMed record(s): 30480800. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biomedical |
submitter keyword: Human,Patent ductus arteriosus, Plasma, Proteomics,LC-MSMS |
Contact List
Hai-Tao Hou |
contact affiliation | Department of basic research center,TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. |
contact email | hhtpk007@163.com |
lab head | |
Hai-Tao Hou |
contact affiliation | Teda International Cardiovascular Hospital |
contact email | hhtpk007@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008568
- Label: PRIDE project
- Name: Human plasma LC-MSMS