PXD008489-2

PXD008489 is an original dataset announced via ProteomeXchange.

Title	Proteomic profile of ET-1 induced dysfunctional hiPS-C cells
Description	A precise investigation on the efficacy of multicomponent drugs against HF using the signature biomarkers-oriented approach was developed in this study and applied to a conventional drug for cardiac disease, YiXinShu (YXS). Based on in vitro and in vivo efficacy evaluation of YXS against HF and with the aid of proteomics and network pharmacology approaches, specific signatures regulated by YXS against HF were confidently confirmed. YXS may show distinctive treatment features for those HF patients showing the elevation of fatty acid-binding protein 3 and cytoskeleton-associated protein 5, as well as other classical HF biomarkers. This study provides the first precise investigation of the efficacy of multicomponent drugs against HF and offers a smarter and low-cost approach for precise medicine in the management of heart failure (HF).
HostingRepository	iProX
AnnounceDate	2017-12-19
AnnouncementXML	Submission_2017-12-19_00:52:58.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Junying Wei
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-18 22:02:56	ID requested
1	2017-12-18 22:03:05	announced
⏵ 2	2017-12-19 00:52:58	announced	Update keyword information.

Dataset with its publication pending

submitter keyword: hiPS-C cells, proteomics

Junying Wei
contact affiliation	Institute of Chinese Materia Medica
contact email	13683350075@163.com
lab head
Junying Wei
contact affiliation	Institute of Chinese Materia Medica
contact email	13683350075@163.com
dataset submitter

iProX dataset URI