PXD008465-2

PXD008465 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Peptidomic analysis of pancreatic neurodendocrine tumours (Glucagonoma)
Description	A peptidomic analysis of plasma from patients with well characterised pancreatic neuroendocrine tumours (PNET) was performed. A nano LC-MS analysis identified a number of peptides from the glucagon gene, which were idenfiried in a previous case study using multiple immunoassays. Peptides to other proteins involved in peptide secretion were also identified. Plasma from a second glucagonoma patient was analysed using a high flow approach, and this identified similar peptides to the nano analysis. In order to demonstrate the potential clinical application of LC-MS to characterising neuroendocrine tumours, a large cohort of plasma samples were analysed to demonstrate the ability of this approach to identify glucagonoma patients, and differentiate from a single insulinoma patient
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:42:39.963.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD008465
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Richard Kay
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Amidated; Oxidation; Acetyl; Gln->pyro-Glu
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-12-15 02:13:53	ID requested
1	2018-06-06 06:25:53	announced
⏵ 2	2024-10-22 04:42:47	announced	2024-10-22: Updated project metadata.

Publication List

10.1002/rcm.8183;
Kay RG, Challis BG, Casey RT, Roberts GP, Meek CL, Reimann F, Gribble FM, Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours. Rapid Commun Mass Spectrom, 32(16):1414-1424(2018) [pubmed]
10.6019/PXD008465;

10.1002/rcm.8183;

Kay RG, Challis BG, Casey RT, Roberts GP, Meek CL, Reimann F, Gribble FM, Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours. Rapid Commun Mass Spectrom, 32(16):1414-1424(2018) [pubmed]

10.6019/PXD008465;

Keyword List

curator keyword: Biomedical
submitter keyword: plasma peptidomics,Pancreatic neuroendocrine tumour, glucagonoma

curator keyword: Biomedical

submitter keyword: plasma peptidomics,Pancreatic neuroendocrine tumour, glucagonoma

Contact List

Professor Fiona Gribble
contact affiliation	Metabolic Research Laboratories, University of Cambridge
contact email	fmg23@cam.ac.uk
lab head
Richard Kay
contact affiliation	University of Cambridge
contact email	rgk27@medschl.cam.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD008465
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/06/PXD008465

PRIDE project URI

Repository Record List

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