PXD008320 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | ALKBH7, a mitochondrial member of AlkB family, binds histones in vitro, part 3 |
Description | Human genome encodes 9 AlkB family members, one of which is ALKBH7. In this study, we found recombinant ALKBH7 could bind bulk histones in GST pull-down and attenuate the signal of H4K20me2 in demethylation assays. With mass spectrometry, we also identified several potential ALKBH7-interacting proteins, such as NDUFS2, MRPS7 etc.; and found the expression of NDUFA4 and COX6C was down-regulated upon knockdown of ALKBH7. With these results, we can obtain a novel sight into the function of this protein |
HostingRepository | PRIDE |
AnnounceDate | 2020-05-26 |
AnnouncementXML | Submission_2020-05-26_11:14:36.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Wei Ge |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-11-29 01:59:47 | ID requested | |
⏵ 1 | 2020-05-26 11:14:37 | announced | |
Publication List
Meng S, Zhan S, Dou W, Ge W, The interactome and proteomic responses of ALKBH7 in cell lines by in-depth proteomics analysis. Proteome Sci, 17():8(2019) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: ALKBH7;mitochondrion;histone |
Contact List
Wei Ge |
contact affiliation | Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College; No. 5 Dongdansantiao, Dongcheng District, Beijing 100005, China |
contact email | wei.ge@chem.ox.ac.uk |
lab head | |
Wei Ge |
contact affiliation | National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences |
contact email | wei.ge@chem.ox.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008320
- Label: PRIDE project
- Name: ALKBH7, a mitochondrial member of AlkB family, binds histones in vitro, part 3