PXD008246-2

PXD008246 is an original dataset announced via ProteomeXchange.

Title	Identification of novel LIMK2 phosphorylation substrates
Description	Breast cancer is the most common and a lethal form of cancer diagnosed in women worldwide. Although, effective treatment options for primary tumors are available, the majority of breast cancer-related deaths is caused by invasion of cells from primary tumor results in metastatic progression. Here we used a phopshoproteomic analysis to identify new targets of pro-invasive LIM kinase 2 (LIMK2) in invasive breast cancer cell lines. We show that Serine Arginine protein kinase 1 (SRPK1) is phosphorylated and activated by LIMK2 and LIMK2-SRPK1 signaling axis mediate the invasive behavior of breast cancer cells.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:11:33.143.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	narendra wajapeyee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2017-11-20 05:40:22	ID requested
1	2020-08-30 22:58:20	announced
⏵ 2	2024-10-22 05:11:34	announced	2024-10-22: Updated project metadata.

Malvi P, Janostiak R, Chava S, Manrai P, Yoon E, Singh K, Harigopal M, Gupta R, Wajapeyee N, LIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1. Oncogenesis, 9(8):77(2020) [pubmed]

10.1038/s41389-020-00263-1;

curator keyword: Biomedical

submitter keyword: breast cancer,LIMK2, phosphorylation, invasion

Narendra Wajapeyee
contact affiliation	Yale University
contact email	Narendra.Wajapeyee@yale.edu
lab head
narendra wajapeyee
contact affiliation	University of Alabama at Birmingham
contact email	nwajapey@uab.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/08/PXD008246

PRIDE project URI

• PRIDE
  1. PXD008246
     1. Label: PRIDE project
     2. Name: Identification of novel LIMK2 phosphorylation substrates