PXD008184 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | PCa_Secretome_PC3vsPC3nKR |
Description | Prostate cancer (PCa) is the most common cancer in American men. The American Cancer Society’s estimates for prostate cancer in the United States for 2017 are estimated 161.360 new cases and 26,730 deaths from PCa. To study metastatic properties to bone, PC-3 cell line is mainly used classical human prostatic carcinoma cell line, established and characterized its tumorigenicity from a human prostatic adenocarcinoma metastatic to bone is reported. In addition, PC-3/nkR cell line, natural killer(NK) cells-resistant, was isolated from mammary tumor xenograft studies in mice from PC-3 was implanted to nude mice and fecund to be tumorigenic in the early 2000s. In this study, we investigated secreted proteins of the conditioned media of PC-3 and PC-3/nkR cell lines using comparative proteomics technology to identify the molecular mechanism related to metastatic processes related to PC-3/nkR. Our study showed PC-3/nkR cells are new highly migrated and NK cells-resistant cell-line compared to PC-3 cells, as novel highly malignant tumor cells to study mechanisms of PCa metastatic. |
HostingRepository | PRIDE |
AnnounceDate | 2019-08-19 |
AnnouncementXML | Submission_2019-08-18_23:58:31.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Oh Kwang Kwon |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-11-10 05:47:25 | ID requested | |
⏵ 1 | 2019-08-18 23:58:32 | announced | |
Publication List
Jeon JM, Kwon OK, Na AY, Sung EJ, Cho IJ, Kim M, Yea SS, Chun SY, Lee JH, Ha YS, Kwon TG, Lee S, Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells. PLoS One, 14(8):e0220807(2019) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Prostate cancer, PC-3, PC-3/nKR, TMT labeling |
Contact List
Sangkyu Lee |
contact affiliation | BK21 Plus KNU Multi-Omics based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Republic of Korea |
contact email | sangkyu@knu.ac.kr |
lab head | |
Oh Kwang Kwon |
contact affiliation | Kyungpook National University |
contact email | kok0100@nate.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD008184 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008184
- Label: PRIDE project
- Name: PCa_Secretome_PC3vsPC3nKR