PXD008098 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative proteomic profiling of cerebrospinal fluid to identify candidate biomarkers for Alzheimer’s disease |
Description | Alzheimer's disease (AD) is the most prevalent form of dementia and the number of AD patients is expected to increase as human life expectancy improves. The deposition of β-amyloid protein (Aβ) in the extracellular matrix and neurofibrillary tangles intracellularly are pathologic hallmarks of AD in the brain. However, there are no reliable circulating biomarkers for accurate diagnosis of AD. In this study, we employed high-resolution mass spectrometry and tandem mass tags (TMT) to identify candidate biomarkers for Alzheimer’s disease. A subset of the identified candidates was validated using multiplexed targeted PRM-LC-MS/MS analysis in an independent cohort. |
HostingRepository | PRIDE |
AnnounceDate | 2019-01-10 |
AnnouncementXML | Submission_2019-01-10_01:30:04.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Akhilesh Pandey |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos; Q Exactive HF; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-11-01 02:21:42 | ID requested | |
⏵ 1 | 2019-01-10 01:30:05 | announced | |
2 | 2024-10-22 04:41:28 | announced | 2024-10-22: Updated project metadata. |
Publication List
Sathe G, Na CH, Renuse S, Madugundu AK, Albert M, Moghekar A, Pandey A, Quantitative Proteomic Profiling of Cerebrospinal Fluid to Identify Candidate Biomarkers for Alzheimer's Disease. Proteomics Clin Appl, 13(4):e1800105(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Human, Alzheimer's disease, Cerebrospinal fluid, Biomarker |
Contact List
Akhilesh Pandey |
contact affiliation | McKusick-Nathans Institute of Genetic Medicine, Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205 USA |
contact email | pandey@jhmi.edu |
lab head | |
Akhilesh Pandey |
contact affiliation | Johns Hopkins University |
contact email | pandey@jhmi.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/01/PXD008098 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD008098
- Label: PRIDE project
- Name: Quantitative proteomic profiling of cerebrospinal fluid to identify candidate biomarkers for Alzheimer’s disease