PXD008022-1

PXD008022 is an original dataset announced via ProteomeXchange.

Title	Glioma proteome organization under oncolytic adenoviral infection
Description	Glioblastoma multiforme (GBM) is the most common and aggressive type of malignant glioma. Oncolytic adenoviruses are being modified to exploit the aberrant expression of proteins in tumor cells to enhance tumor tropism and glioma-selective replication. E1A mutant adenovirus Delta-24-RGD has shown favorable toxicity profile and remarkable efficacy in a first-in-human phase I clinical trial. However, the comprehensive modulation of glioma metabolism in response to Delta-24-RGD infection is poorly understood. Integrating mass spectrometry based-quantitative proteomics, physical and functional interaction data, and biochemical approaches, we conducted a cell-wide study of cytosolic, nuclear, and secreted glioma proteomes throughout the early time course of Delta-24-RGD infection.
HostingRepository	PRIDE
AnnounceDate	2018-10-22
AnnouncementXML	Submission_2018-10-22_10:53:45.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Enrique Santamaría
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue; acetylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2017-10-23 05:27:57	ID requested
⏵ 1	2018-10-22 10:53:46	announced
2	2024-10-22 04:36:35	announced	2024-10-22: Updated project metadata.

Gonz, á, lez-Morales A, Zabaleta A, Guruceaga E, Alonso MM, Garc, í, a-Moure M, Fern, á, ndez-Irigoyen J, Santamar, í, a E, Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection. Oncotarget, 9(57):31045-31065(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: glioma, proteomics, adenovirus

enrique santamaria
contact affiliation	neuroproteomics Lab Navarrabiomed-Proteored
contact email	esantamma@navarra.es
lab head
Enrique Santamaría
contact affiliation	Proteomics unit
contact email	esantamma@navarra.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD008022

PRIDE project URI

• PRIDE
  1. PXD008022
     1. Label: PRIDE project
     2. Name: Glioma proteome organization under oncolytic adenoviral infection