PXD007971-2

PXD007971 is an original dataset announced via ProteomeXchange.

Title	In-depth analysis of differential protein expression in patients greater than 45 years old with papillary thyroid cancer through quantitative proteomics
Description	Papillary thyroid cancer (PTC) accounts for the predominant histological types of all thyroid cancers. Additionally, 15% PTC with LNM are unfortunately associated with increased radioiodine resistance, distant metastasis, recurrence and increased mortality. Additionally, 15% PTC with LNM are unfortunately associated with increased radioiodine resistance, distant metastasis, recurrence and increased mortality.Two proteomics research has been implemented to investigate the molecular mechanisms involved in pathogenesis of PTC patients younger than 45 years with LNM and identified several candidate biomarker.However, until now there is no study to comprehensively investigate the differential expressed proteins (DEPs) in PTC patients older than age 45 years.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:37:39.186.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Ge
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-10-16 03:56:50	ID requested
1	2022-06-09 03:36:23	announced
⏵ 2	2024-10-22 05:37:40	announced	2024-10-22: Updated project metadata.

Zhan S, Wang T, Li J, Zhu H, Ge W, Li J, the MAPK/EMT Signaling Pathway. Front Oncol, 12():762180(2022) [pubmed]

10.3389/fonc.2022.762180;

curator keyword: Biomedical

submitter keyword: quantitative proteomics,PTC, 45 years

Wei Ge
contact affiliation	Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, National Key Laboratory of Medical Molecular Biology & Department of Immunology, No 5 Dongdan Santiao, Dongcheng district, Beijing 100005, China.
contact email	wei.ge@chem.ox.ac.uk
lab head
Wei Ge
contact affiliation	National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
contact email	wei.ge@chem.ox.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/06/PXD007971

PRIDE project URI

• PRIDE
  1. PXD007971
     1. Label: PRIDE project
     2. Name: In-depth analysis of differential protein expression in patients greater than 45 years old with papillary thyroid cancer through quantitative proteomics