PXD007869-1

PXD007869 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Analysis of peripheral neuron protein expression in the absence of Ikbkap/Elp1
Description	Familial dysautonomia (FD) results from mutation in IKBKAP/ELP1, a gene encoding the scaffolding protein for the Elongator complex. This highly conserved complex is required for the methoxy-carbonyl-methyl (mcm5) modification of uridines located in the wobble position of tRNA molecules (U34). In FD, the peripheral nervous system is particularly devastated by loss of IKBKAP. Here we investigate protein expression within the dorsal root ganglia (DRG) of a mouse model of FD. In this model, Ikbkap is selectively deleted in the neural crest lineage using a Wnt1-Cre transgene and floxed Ikbkap. DRG were collected and pooled from seven Ikbkap conditional knockout (Wnt1-Cre;IkbkapLoxP/LoxP) and seven control E17.5 mice and analyzed via UHPLC-MS/MS.
HostingRepository	MassIVE
AnnounceDate	2018-11-01
AnnouncementXML	Submission_2018-11-01_08:36:40.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joy Goffena
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	unknown modification: PRIDE:0000398
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-28 07:29:34	ID requested
⏵ 1	2018-11-01 08:36:40	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Mouse, dorsal root ganglia, DRG, Ikbkap, IKAP, Elongator, familial dysautonomia, FD

submitter keyword: Mouse, dorsal root ganglia, DRG, Ikbkap, IKAP, Elongator, familial dysautonomia, FD

Contact List

Lynn D George
contact affiliation	Montana State University Billings
contact email	lynn.george@msubillings.edu
lab head
Joy Goffena
contact affiliation	Montana State Univ Billings
contact email	jgoffena@msubillings.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000081568