PXD007741-2

PXD007741 is an original dataset announced via ProteomeXchange.

Title	Identifying host factors associated with DNA replicated during virus infection
Description	Viral DNA genomes replicating in cells encounter a myriad of host factors that facilitate or hinder viral replication. Viral proteins expressed early during infection modulate host factors interacting with viral genomes, recruiting proteins to promote viral replication, and limiting access to antiviral repressors. Although some host factors manipulated by viruses have been identified, we know little about pathways exploited during infection and how these differ between viruses. To identify cellular processes manipulated during viral replication, we defined proteomes associated with viral genomes during infection with adenovirus, herpes simplex virus and vaccinia virus. We compared enrichment of host factors between virus proteomes and confirmed association with viral genomes and replication compartments. Using adenovirus as an illustrative example, we uncovered host factors deactivated by early viral proteins, and identified a subgroup of nucleolar proteins that aid virus replication. Our datasets provide valuable resources of virus-host interactions that affect proteins on viral genomes.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:40:36.475.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Katarzyna Kulej
SpeciesList	scientific name: Herpesvirales; NCBI TaxID: 548681; scientific name: Vaccinia virus WR; NCBI TaxID: 10254; scientific name: Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5); NCBI TaxID: 28285; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	mono N-acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2017-09-14 01:55:51	ID requested
1	2017-10-05 00:14:36	announced
⏵ 2	2024-10-22 04:40:44	announced	2024-10-22: Updated project metadata.

Reyes ED, Kulej K, Pancholi NJ, Akhtar LN, Avgousti DC, Kim ET, Bricker DK, Spruce LA, Koniski SA, Seeholzer SH, Isaacs SN, Garcia BA, Weitzman MD, Identifying Host Factors Associated with DNA Replicated During Virus Infection. Mol Cell Proteomics, 16(12):2079-2097(2017) [pubmed]

10.1074/mcp.m117.067116;

curator keyword: Biological

submitter keyword: virus infection / DNA replication / DNA repair / intrinsic defense

Matthew D. Weitzman
contact affiliation	Department of Pathology and Laboratory Medicine,University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA Division of Cancer Pathobiology,Children's Hospital of Philadelphia, Philadelphia, PA USA
contact email	weitzmanm@email.chop.edu
lab head
Katarzyna Kulej
contact affiliation	Children's Hospital of Philadelphia
contact email	kulej.katarzyna@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/10/PXD007741

PRIDE project URI

• PRIDE
  1. PXD007741
     1. Label: PRIDE project
     2. Name: Identifying host factors associated with DNA replicated during virus infection