PXD007590 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Characterization of Spp1-TAP and Mer2-TAP interactomes |
Description | Histone H3K4 methylation is a feature of meiotic recombination hotspots shared by many organisms including plants and mammals. Meiotic recombination is initiated by programmed double strand break (DSB) formation that in budding yeast is directed in gene promoters by histone H3K4 di/trimethylation. This histone modification is indeed recognized by Spp1, a PHD-finger containing protein that belongs to the conserved histone H3K4 methyltransferase Set1 complex. During meiosis, Spp1 binds H3K4me and recruits a DSB protein, Mer2, to promote DSB formation close to gene promoters. How Set1C and Mer2 related functions of Spp1 are connected is not clear. |
HostingRepository | PRIDE |
AnnounceDate | 2018-01-30 |
AnnouncementXML | Submission_2018-02-23_04:20:37.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yohann Couté |
SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-08-29 07:45:01 | ID requested | |
1 | 2018-01-30 08:34:23 | announced | |
⏵ 2 | 2018-02-23 04:20:38 | announced | Updated publication reference for PubMed record(s): 29444071. |
Publication List
Adam C, Gu, é, rois R, Citarella A, Verardi L, Adolphe F, B, é, neut C, Sommermeyer V, Ramus C, Govin J, Cout, é Y, Borde V, The PHD finger protein Spp1 has distinct functions in the Set1 and the meiotic DSB formation complexes. PLoS Genet, 14(2):e1007223(2018) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Saccharomyces cerevisiae, meiosis, Spp1, Mer2, interactomics |
Contact List
Virginie Brun |
contact affiliation | EDyP |
contact email | virginie.brun@cea.fr |
lab head | |
Yohann Couté |
contact affiliation | Laboratoire d'Etude de la Dynamique des Protéomes |
contact email | yohann.coute@cea.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007590
- Label: PRIDE project
- Name: Characterization of Spp1-TAP and Mer2-TAP interactomes