PXD007567 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Combined proteomics/genomics approach reveals proteomic changes of mature virions as a novel poxvirus adaption mechanism |
Description | DNA viruses, like poxviruses, possess a highly stable genome, suggesting adaption of virus particles to specific cell types is not restricted to genomic changes. Cowpox viruses (CPXV) are zoonotic poxviruses with an extraordinary broad host range, demonstrating their adaptive potential in vivo. To elucidate novel adaption mechanisms of poxviruses, we isolated CPXV particles from a rat and passaged them five times in a human (HEp-2) and a rat (Rat-2) cell line. Subsequently, we purified mature virions and compared the proteome of the non-passaged virions and each passage. |
HostingRepository | PRIDE |
AnnounceDate | 2017-11-14 |
AnnouncementXML | Submission_2017-11-14_01:02:10.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marica Grossegesse |
SpeciesList | scientific name: Cowpox virus (CPV); NCBI TaxID: 10243; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitap Discovery |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-08-28 02:05:18 | ID requested | |
⏵ 1 | 2017-11-14 01:02:11 | announced | |
Publication List
Grossegesse M, Doellinger J, Tyshaieva A, Schaade L, Nitsche A, Combined Proteomics/Genomics Approach Reveals Proteomic Changes of Mature Virions as a Novel Poxvirus Adaptation Mechanism. Viruses, 9(11):(2017) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Poxvirus, Cowpox virus, adaption, LC-MS/MS |
Contact List
Andreas Nitsche |
contact affiliation | Robert Koch Institute, Centre for Biological Threats and Special Pathogens (ZBS1), Berlin, Germany |
contact email | NitscheA@rki.de |
lab head | |
Marica Grossegesse |
contact affiliation | Robert Koch Institute |
contact email | GrossegesseM@rki.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/11/PXD007567 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007567
- Label: PRIDE project
- Name: Combined proteomics/genomics approach reveals proteomic changes of mature virions as a novel poxvirus adaption mechanism