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PXD007543 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA compendium of co-regulated protein complexes in breast cancer reveals collateral loss events
DescriptionProtein complexes are responsible for the bulk of activities within the cell, but how their behavior and abundance varies across tumors remains poorly understood. By combining proteomic profiles of breast tumors with a large-scale protein-protein interaction network, we have identified a set of 285 high-confidence protein complexes whose subunits have highly correlated protein abundance across tumor samples. We used this set to identify complexes that are reproducibly under- or over-expressed in specific breast cancer subtypes. We found that mutation or deletion of one subunit of a co-regulated complex was often associated with a collateral reduction in protein expression of additional complex members. This collateral loss phenomenon was typically evident from proteomic, but not transcriptomic, profiles suggesting post- transcriptional control. Mutation of the tumor suppressor E-cadherin (CDH1) was associated with a collateral loss of members of the adherens junction complex, an effect we validated using an engineered model of E-cadherin loss.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSusan Kennedy
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-08-24 02:36:31ID requested
12018-10-01 08:04:06announced
Publication List
Ryan CJ, Kennedy S, Bajrami I, Matallanas D, Lord CJ, A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events. Cell Syst, 5(4):399-409.e5(2017) [pubmed]
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: protein complex, breast cancer, protein-protein interaction, collateral loss
Contact List
Colm Ryan
contact affiliationSystems Biology Ireland, University College Dublin, Ireland
contact emailcolm.ryan@ucd.ie
lab head
Susan Kennedy
contact affiliationSystems Biology Ireland, University College Dublin.
contact emailsusan.kennedy@ucd.ie
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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