PXD007188-1

PXD007188 is an original dataset announced via ProteomeXchange.

Title	Mevalonate pathway activity is a key determinant of radiation sensitivity in head and neck cancer
Description	Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here we report a novel role for statin-based treatment of HNSCCs as an actionable and safe adjuvant to radiotherapy. Proteomic profiling and comparison of radiosensitive and radioresistant HNSCCs revealed differential regulation of the mevalonate biosynthetic pathway. Consistent with this finding, inhibition of the mevalonate pathway by pitavastatin (and other related statins) sensitized SQ20B cells to ionizing radiation (IR) and reduced their clonogenic potential. In an effort to uncover the mechanism behind this statin-mediated sensitization, we analyzed prenylation of several important cellular targets upon combined IR-statin treatment. Overall, this study reinforces the view that the mevalonate pathway is a promsing novel therapeutic target in radioresistant HSNCCs.
HostingRepository	PRIDE
AnnounceDate	2019-06-25
AnnouncementXML	Submission_2019-06-25_01:15:22.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD007188
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Donald Wolfgeher
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Ammonia-loss; Deamidated; Formyl; Dehydrated; Oxidation; Acetyl; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-08-04 04:11:06	ID requested
⏵ 1	2019-06-25 01:15:23	announced

Ricco N, Flor A, Wolfgeher D, Efimova EV, Ramamurthy A, Appelbe OK, Brinkman J, Truman AW, Spiotto MT, Kron SJ, Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer. Mol Oncol, 13(9):1927-1943(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: HNSCC, pitavastatin, mevalonate pathway, DDR, senescence, Q-Exactive, LFQ Quantification.

Dr. Stephen J Kron
contact affiliation	Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA.
contact email	skron@uchicago.edu
lab head
Donald Wolfgeher
contact affiliation	University of Chicago
contact email	donw@uchicago.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD007188
     1. Label: PRIDE project
     2. Name: Mevalonate pathway activity is a key determinant of radiation sensitivity in head and neck cancer