PXD007171-2

PXD007171 is an original dataset announced via ProteomeXchange.

Title	Dynamic adaptation of myocardial proteome during heart failure development after induction of left ventricular pressure overload in mice
Description	We analyzed time dependent global proteomic adaptations during heart failure (HF) progression in a mouse model, suffering from left ventricular pressure overload due to transverse aortic constriction (TAC), to gain deeper insights in the disease development and identify new biomarker candidates. The hearts from TAC and sham mice were examined by cardiac MRI on either day 4, 14, 21, 28, 42, and 56 after surgery (n=6 group/time point). At each time point, proteomes of the left (LV) and right ventricles (RV) of TAC and sham mice were analyzed by mass spectrometry (MS).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:39:57.103.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Benkner
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-08-02 03:01:15	ID requested
1	2018-07-16 00:54:03	announced
⏵ 2	2024-10-22 04:40:05	announced	2024-10-22: Updated project metadata.

R, ü, debusch J, Benkner A, Poesch A, D, ö, rr M, V, ö, lker U, Grube K, Hammer E, Felix SB, Dynamic adaptation of myocardial proteome during heart failure development. PLoS One, 12(10):e0185915(2017) [pubmed]

10.1371/journal.pone.0185915;

curator keyword: Biological, Biomedical

submitter keyword: heart failure, HSPB7, left ventricle, proteome, right ventricle

Uwe Völker
contact affiliation	Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
contact email	voelker@uni-greifswald.de
lab head
Alexander Benkner
contact affiliation	University Medicine Greifswald
contact email	benknera@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD007171

PRIDE project URI

• PRIDE
  1. PXD007171
     1. Label: PRIDE project
     2. Name: Dynamic adaptation of myocardial proteome during heart failure development after induction of left ventricular pressure overload in mice