PXD007137-2

PXD007137 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Ceritinib Functional Proteomics
Description	To elucidate the mechanism of action (MoA) of ceritinib’s antiproliferative activity in these cells, we applied a systems approach combining both chemical and phosphoproteomics to gain a global view of ceritinib’s target profile and network-wide phosphorylation changes following ceritinib treatment.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:39:50.421.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD007137
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Brent Kuenzi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Phospho; Label:13C(6)15N(4); Oxidation; Label:13C(6); Carbamidomethyl
Instrument	Q Exactive; LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-26 08:33:50	ID requested
1	2018-01-12 05:57:01	announced
⏵ 2	2024-10-22 04:39:58	announced	2024-10-22: Updated project metadata.

Publication List

10.6019/PXD007137;
Kuenzi BM, Remsing Rix LL, Stewart PA, Fang B, Kinose F, Bryant AT, Boyle TA, Koomen JM, Haura EB, Rix U, Polypharmacology-based ceritinib repurposing using integrated functional proteomics. Nat Chem Biol, 13(12):1222-1231(2017) [pubmed]
10.1038/nchembio.2489;

10.6019/PXD007137;

Kuenzi BM, Remsing Rix LL, Stewart PA, Fang B, Kinose F, Bryant AT, Boyle TA, Koomen JM, Haura EB, Rix U, Polypharmacology-based ceritinib repurposing using integrated functional proteomics. Nat Chem Biol, 13(12):1222-1231(2017) [pubmed]

10.1038/nchembio.2489;

Keyword List

curator keyword: Biomedical
submitter keyword: phosphoproteomics,Chemical proteomics

curator keyword: Biomedical

submitter keyword: phosphoproteomics,Chemical proteomics

Contact List

Uwe Rix
contact affiliation	Moffitt Cancer Center
contact email	uwe.rix@moffitt.org
lab head
Brent Kuenzi
contact affiliation	Moffitt Cancer Center
contact email	brent.kuenzi@moffitt.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD007137
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD007137

PRIDE project URI

Repository Record List

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