PXD007124-1

PXD007124 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics of barrier-deficient mouse epidermis in response to environmental humidity
Description	Low environmental humidity aggravates symptoms of inflammatory skin diseases, e.g. of Atopic Dermatitis (AD). Using mice that develop AD-like symptoms, we show that an increase in environmental humidity rapidly rescues their cutaneous inflammation and associated epidermal abnormalities. Quantitative proteomics analysis of epidermal lysates of mice kept at low or high humidity identified novel humidity-regulated proteins, including Clca2/Clca3a2, a protein with previously unknown function in the skin.
HostingRepository	PRIDE
AnnounceDate	2018-05-14
AnnouncementXML	Submission_2018-05-14_00:22:52.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ulrich auf dem Keller
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	methylthiolated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-25 03:35:32	ID requested
⏵ 1	2018-05-14 00:22:54	announced
2	2024-10-22 04:39:23	announced	2024-10-22: Updated project metadata.

Seltmann K, Meyer M, Sulcova J, Kockmann T, Wehkamp U, Weidinger S, Auf dem Keller U, Werner S, Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress. Sci Transl Med, 10(440):(2018) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: mouse, skin, epidermis, barrier defect, humidity, osmoregulation

Sabine Werner
contact affiliation	ETH Zurich, Department of Biology, Institute of Molecular Health Sciences
contact email	sabine.werner@biol.ethz.ch
lab head
Ulrich auf dem Keller
contact affiliation	Institute of Molecular Health Research
contact email	ulrich.aufdemkeller@cell.biol.ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD007124

PRIDE project URI

• PRIDE
  1. PXD007124
     1. Label: PRIDE project
     2. Name: Quantitative proteomics of barrier-deficient mouse epidermis in response to environmental humidity