PXD007085 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | An immunoproteomic approach to characterize the CAR interactome and signalosome |
Description | Adoptive transfer of chimeric antigen receptor (CAR)-T cells is expected to become the first line of treatment for multiple malignancies, following the enormous success of anti-CD19 therapies. However, their mechanism of action is not fully understood, and clear guidelines for the design of safe and efficient receptors are missing. We hereby describe a systematic analysis of the CAR “interactome” in human primary T cells, which allowed us to identify molecular traits that influence CAR-T cell efficacy. Interactome analysis was based on immunoprecipitation of CARs followed by protein identification by mass spectrometry. |
HostingRepository | PRIDE |
AnnounceDate | 2019-11-07 |
AnnouncementXML | Submission_2019-11-06_23:38:08.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD007085 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | John Koomen |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-07-20 02:56:03 | ID requested | |
⏵ 1 | 2019-11-06 23:42:52 | announced | |
Publication List
Ramello MC, Benza, ï, d I, Kuenzi BM, Lienlaf-Moreno M, Kandell WM, Santiago DN, Pab, ó, n-Salda, ñ, a M, Darville L, Fang B, Rix U, Yoder S, Berglund A, Koomen JM, Haura EB, Abate-Daga D, An immunoproteomic approach to characterize the CAR interactome and signalosome. Sci Signal, 12(568):(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Chimeric Antigen Receptors, Interactome, Tonic Signaling |
Contact List
Daniel Abate-Daga |
contact affiliation | Moffitt Cancer Center |
contact email | daniel.abatedaga@moffitt.org |
lab head | |
John Koomen |
contact affiliation | Moffitt Cancer Center |
contact email | john.koomen@moffitt.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD007085 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD007085
- Label: PRIDE project
- Name: An immunoproteomic approach to characterize the CAR interactome and signalosome