PXD006912-1

PXD006912 is an original dataset announced via ProteomeXchange.

Title	Escherichia coli msbB-deficient mutant extracellular vesicle proteome
Description	Bacteria actively secrete extracellular vesicles (EVs), spherical nano-sized proteolipids into the extracellular milieu. Bacterial EVs have gained wide interests as non-living complex vaccines or delivery vehicles. However, no studies have used bacterial EVs in treating cancer so far. Our results showed remarkable capability of EVs derived from Escherichia coli W3110 msbB-deficient mutant to effectively induce long-term anti-tumor immune responses that can fully eradicate established tumors without notable adverse effects. This anti-tumor effect was IFN-γ-dependent, and we present a comprehensive proteome of E. coli W3110 msbB-deficient EVs to investigate which vesicular components induce the anti-tumor effects.
HostingRepository	PRIDE
AnnounceDate	2018-11-22
AnnouncementXML	Submission_2018-11-22_01:59:57.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yong Song Gho
SpeciesList	scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationList	dehydrated residue; deaminated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2017-07-10 02:43:37	ID requested
⏵ 1	2018-11-22 01:59:59	announced
2	2024-10-22 04:39:32	announced	2024-10-22: Updated project metadata.

Kim OY, Park HT, Dinh NTH, Choi SJ, Lee J, Kim JH, Lee SW, Gho YS, -mediated antitumor response. Nat Commun, 8(1):626(2017) [pubmed]

curator keyword: Biological

submitter keyword: Escherichia coli, extracellular vesicles, exosomes, outer membrane vesicles, bacteria

Yong Song Gho
contact affiliation	Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
contact email	ysgho@postech.ac.kr
lab head
Yong Song Gho
contact affiliation	Department of Life Science
contact email	ysgho@postech.ac.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD006912

PRIDE project URI

• PRIDE
  1. PXD006912
     1. Label: PRIDE project
     2. Name: Escherichia coli msbB-deficient mutant extracellular vesicle proteome