PXD006863 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | TMT-FASP-LC-MS analysis of peritoneal dialysis effluent |
Description | Peritoneal dialysis (PD) is a modality of renal replacement therapy in which the high volumes of available PD effluent (PDE) represents a rich source of biomarkers for monitoring disease and therapy. Although this information could help guiding the management of PD patients, little is known about the potential of PDE to define pathomechanism-associated molecular signatures in PD. Here we present the utilization of a high-performance multiplex proteomics approach based on depletion of highly abundant plasma proteins and enrichment of low abundance proteins and quantitation using a combination of label-free and isobaric labeling strategies for PDE samples from PD patients (n=20), who received either standard PD fluid or a novel PD fluid (added alanyl-glutamine (AlaGln)) in an open-label, randomized, two-period, cross-over clinical trial. |
HostingRepository | PRIDE |
AnnounceDate | 2018-01-05 |
AnnouncementXML | Submission_2018-01-05_00:30:30.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD006863 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Klaus Kratochwill |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex; Oxidation; Carbamidomethyl |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-07-03 23:38:17 | ID requested | |
1 | 2017-12-13 06:34:47 | announced | |
⏵ 2 | 2018-01-05 00:30:31 | announced | Updated project metadata. |
Publication List
Herzog R, Boehm M, Unterwurzacher M, Wagner A, Parapatics K, M, รก, jek P, Mueller AC, Lichtenauer A, Bennett KL, Alper SL, Vychytil A, Aufricht C, Kratochwill K, Effects of Alanyl-Glutamine Treatment on the Peritoneal Dialysis Effluent Proteome Reveal Pathomechanism-Associated Molecular Signatures. Mol Cell Proteomics, 17(3):516-532(2018) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: peritoneal dialysis, plasma proteins, biomarkers, TMT, cytoprotection |
Contact List
Klaus Kratochwill |
contact affiliation | Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria |
contact email | klaus.kratochwill@meduniwien.ac.at |
lab head | |
Klaus Kratochwill |
contact affiliation | Medical University of Vienna |
contact email | klaus.kratochwill@meduniwien.ac.at |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006863
- Label: PRIDE project
- Name: TMT-FASP-LC-MS analysis of peritoneal dialysis effluent